International Journal of Polymeric Materials· 2026Q2· Review
Polymer-based in-situ gelling nanoplatforms for buccal drug delivery: a comprehensive review of advances and challenges
- 0citations
- Q2SCImago
- 2026year
Short summary
Polymer-based nanoplatforms that form gels in-situ show promise for buccal drug delivery, overcoming challenges of rapid clearance and oral movement by enhancing mucoadhesion and drug retention.
AI-generated from the title and abstract; the full text is not read.
Key points
- Buccal drug delivery bypasses first-pass metabolism but faces issues with saliva clearance and oral movement.
- In-situ gelling nanoplatforms using natural (gellan gum, chitosan) and synthetic (poloxamers, PLGA) polymers enhance mucoadhesion and gel formation.
- Nanocarriers (polymeric nanoparticles, liposomes, micelles) improve drug solubility, stability, and targeting.
- Preclinical and clinical results are promising for oral diseases and systemic therapies.
- Challenges include formulation stability, manufacturing, regulatory approval, and clinical validation.
AI-generated from the title and abstract; the full text is not read.
Abstract
The buccal route offers a promising alternative for local and systemic drug delivery by utilizing the oral mucosa’s high permeability to bypass first-pass metabolism and enhance bioavailability. However, rapid saliva clearance and continuous oral movements pose challenges to drug retention, often requiring frequent re-dosing. This review highlights the potential of nanocarrier-based in-situ gelling systems that utilize both natural (e.g., gellan gum, chitosan) and synthetic (e.g., poloxamers, PLGA) polymers to enhance mucoadhesion and gel formation. Nanocarriers like polymeric nanoparticles, liposomes, and micelles enhance drug solubility, stability, and targeting. Promising preclinical and clinical results indicate their effectiveness in treating oral diseases and delivering systemic therapies, though challenges in formulation stability, manufacturing, regulatory approval, and clinical validation remain. Addressing these hurdles is essential to fully realize the potential of these systems, making nanocarrier-mediated in-situ gels a versatile approach to improving bioavailability and patient compliance.
The authors' abstract, as published at the source. International Journal of Polymeric Materials, 2026 · DOI ↗
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Field: Pharmaceutical Science
Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics