Journal of Agricultural and Food Chemistry· 2026Q1
Isovitexin Attenuates Aβ-Induced Neurotoxicity by Activating SKN-1/Nrf2 Signaling and Suppressing Ferroptosis in Caenorhabditis elegans Models of Alzheimer’s Disease
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- Q1SCImago
- 2026year
Short summary
Isovitexin, a flavonoid from dark tea, significantly reduces Alzheimer's-associated amyloid-beta (Aβ) buildup and neurotoxicity in C. elegans models.
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Key points
- Isovitexin, a flavonoid from dark tea, shows significant neuroprotective effects in C. elegans AD models.
- It reduces amyloid-beta (Aβ) accumulation and improves neuromuscular function.
- Isovitexin activates SKN-1/Nrf2 signaling.
- This activation suppresses Aβ-induced ferroptosis and mitochondrial dysfunction.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by β-amyloid (Aβ) deposition, oxidative stress, ferroptosis, and mitochondrial dysfunction, while effective therapeutic interventions remain limited. Epidemiological evidence indicates that tea and flavonoids with antiaging properties lower AD risk. In this study, untargeted metabolomic profiling identified isovitexin as a differentially abundant flavonoid in postfermented dark tea (DT), and Caenorhabditis elegans (C. elegans) AD models were employed to evaluate its anti-AD potential and elucidate the underlying molecular mechanisms. The results showed that isovitexin significantly extended lifespan, reduced Aβ accumulation, and improved neuromuscular function, demonstrating marked neuroprotective effects. Mechanistically, isovitexin mitigated Aβ-triggered toxicity through SKN-1 signaling, accompanied by the attenuation of Aβ-evoked ferroptosis and mitochondrial dysfunction. Collectively, these results broaden the therapeutic potential of dark tea flavonoids and support further investigation of isovitexin as a candidate for mitigating Aβ-induced neurodegeneration.
The authors' abstract, as published at the source. Journal of Agricultural and Food Chemistry, 2026 · DOI ↗
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Field: Physiology
PhysiologyMedicine