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Acta Neuropathologica Communications· 2026Q1

Loss of GlialCAM cytoplasmic signaling drives cerebellar white matter vacuolation through glial reprogramming and disrupted cell-cell communication

Zahra Nassiri Toosi, Santiago A. Forero, Ali Pirani, S. Sebastian et al.

Short summary

Deleting the cytoplasmic tail of GlialCAM in mice (GCAMΔCT model) leads to progressive cerebellar white matter vacuolation, motor deficits, and memory impairment.

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Field: Developmental Neuroscience

Developmental NeuroscienceNeuroscience