Advanced Science· 2026Q1

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Yimei Li, Mary Ann T. Go, Hualong Zhang, Robertas Aleksynas et al.

3citations
Q1SCImago
2026year

Short summary

Alzheimer's disease model mice show impaired task-related place cell and contextual representations in hippocampal CA1 at 2-4 months, before overt learning deficits appear.

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Field: Physiology

PhysiologyMedicine