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Nature Communications· 2026Q1

A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation

Elisabeth Holzer, Justyna Sawa‐Makarska, Daniel Bernklau, Julia Romanov et al.

Short summary

Autophagy initiation relies on ATG9A compartments, which are activated by a lipid transfer-driven feedback loop involving ATG2A and ATG8 proteins, enabling PI3P production and phagophore expansion.

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Field: Epidemiology

EpidemiologyMedicine