Frontiers in Physiology· 2026Q2
Treadmill exercise improves motor deficits and partially normalizes electrophysiological properties of substantia nigra pars reticulata PV-lineage neurons in 6-OHDA-lesioned mice
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- Q2SCImago
- 2026year
Short summary
Six weeks of treadmill exercise partially improved motor deficits and normalized key electrophysiological properties (input resistance, action potential threshold, firing capacity, adaptation) in substantia nigra pars reticulata (SNr) PV-lineage neurons in 6-OHDA-lesioned mice.
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Key points
- Treadmill exercise for 6 weeks partially improved motor function in 6-OHDA-lesioned mice.
- Exercise partially normalized input resistance and action potential threshold in SNr PV-lineage neurons.
- Evoked firing capacity and firing adaptation of lesioned SNr PV-lineage neurons were also partially normalized by exercise.
- No significant changes in PV protein levels were observed between groups.
AI-generated from the title and abstract; the full text is not read.
Abstract
Objective To examine whether treadmill exercise improves motor deficits and alters electrophysiological properties of substantia nigra pars reticulata (SNr) PV-lineage neurons in 6-OHDA-lesioned mice. Methods Male Pvalb-Cre;Ai14 mice were assigned to Sham, 6-OHDA-lesioned sedentary (PD), and 6-OHDA-lesioned treadmill-exercise (PD+EX) groups. A unilateral 6-OHDA lesion model was established by right striatal injection of 6-OHDA. PD+EX mice underwent treadmill training for 30 min/day, 5 days/week for 6 weeks. Motor function was assessed using a 10-min open-field test and three 300-s rotarod trials. Lesion verification, PV Western blotting, and whole-cell patch-clamp recordings of SNr PV-lineage neurons were performed. Results Six weeks of treadmill exercise partially improved open-field and rotarod performance in 6-OHDA-lesioned mice. Exercise was also accompanied by partial normalization of several electrophysiological abnormalities in lesioned-side SNr PV-lineage neurons, including input resistance, action potential threshold, evoked firing capacity, F–I gain, and firing adaptation. No significant group differences in regional PV protein abundance were observed. Conclusion Treadmill exercise improved motor performance and was accompanied by partial normalization of the electrophysiological properties of SNr PV-lineage neurons in 6-OHDA-lesioned mice.
The authors' abstract, as published at the source. Frontiers in Physiology, 2026 · DOI ↗
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Field: Developmental Neuroscience
Developmental NeuroscienceNeuroscience