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Journal of Orthopaedic Surgery and Research· 2026Q1

Comparative efficacy and safety of intra-articular versus intravenous tranexamic acid in primary total knee arthroplasty: a systematic review and meta-analysis

Kawthar Faisal Kushara, Mayar Ahmed Gasim, Bushra Wadi Bin Saddiq, Ahmed Salah Morad et al.

Short summary

Intra-articular (IA) tranexamic acid (TXA) administration in primary total knee arthroplasty (TKA) was associated with lower total blood loss (p=0.004) and reduced drain output (p=0.04) compared to intravenous (IV) TXA, though with substantial heterogeneity across studies.

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Field: Biochemistry

BiochemistryMedicine