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BMC Medical Informatics and Decision Making· 2026Q1

Development and external validation of an explainable machine learning model for risk stratification of patients with chronotropic incompetence undergoing exercise stress SPECT-MPI: a dual-center study

Shuai Yang, Ruijie Ma, Weiwei Xie, Chunxia Xie et al.

Short summary

An explainable XGBoost machine learning model, integrating clinical, exercise, and SPECT-MPI data, accurately stratified cardiovascular risk in patients with chronotropic incompetence, achieving a 5-year AUC of 0.884 in external validation, outperforming traditional models.

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Field: Complementary and alternative medicine

Complementary and alternative medicineMedicine