Chemical Reviews· 2017Q1· Review
Recent Advances in Radical C–H Activation/Radical Cross-Coupling
- 1,306citations
- Q1SCImago
- 2017year
Short summary
Radical C–H activation/radical cross-coupling reactions offer atom- and step-economical ways to connect molecular fragments, complementary to traditional methods.
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Key points
- Radical C–H activation/radical cross-coupling offers atom- and step-economical molecular assembly.
- Photocatalysis and first-row transition metal catalysis are key enablers.
- Peroxides serve as common radical initiators.
- Methodologies cover radical addition, cascade cyclization, and cross-coupling with M-R groups or nucleophiles.
AI-generated from the title and abstract; the full text is not read.
Abstract
Research and industrial interest in radical C-H activation/radical cross-coupling chemistry has continuously grown over the past few decades. These reactions offer fascinating and unconventional approaches toward connecting molecular fragments with high atom- and step-economy that are often complementary to traditional methods. Success in this area of research was made possible through the development of photocatalysis and first-row transition metal catalysis along with the use of peroxides as radical initiators. This Review provides a brief and concise overview of the current status and latest methodologies using radicals or radical cations as key intermediates produced via radical C-H activation. This Review includes radical addition, radical cascade cyclization, radical/radical cross-coupling, coupling of radicals with M-R groups, and coupling of radical cations with nucleophiles (Nu).
The authors' abstract, as published at the source. Chemical Reviews, 2017 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry