Angewandte Chemie International Edition· 2015Q1· Review
Frustrated Lewis Pair Chemistry: Development and Perspectives
- 1,756citations
- Q1SCImago
- 2015year
Short summary
Frustrated Lewis pairs (FLPs), Lewis acids and bases prevented from forming strong adducts, enable novel cooperative reactions with substrates, notably metal-free catalytic hydrogenations.
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Key points
- FLPs are Lewis acid-base pairs that do not form strong adducts due to steric/electronic factors.
- This frustration enables novel cooperative reactions with substrates.
- FLPs are particularly effective in activating small molecules.
- Metal-free catalytic hydrogenation is a key application of FLPs.
AI-generated from the title and abstract; the full text is not read.
Abstract
Frustrated Lewis pairs (FLPs) are combinations of Lewis acids and Lewis bases in solution that are deterred from strong adduct formation by steric and/or electronic factors. This opens pathways to novel cooperative reactions with added substrates. Small-molecule binding and activation by FLPs has led to the discovery of a variety of new reactions through unprecedented pathways. Hydrogen activation and subsequent manipulation in metal-free catalytic hydrogenations is a frequently observed feature of many FLPs. The current state of this young but rapidly expanding field is outlined in this Review and the future directions for its broadening sphere of impact are considered.
The authors' abstract, as published at the source. Angewandte Chemie International Edition, 2015 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry