Chemical Reviews· 2018Q1· Review
Pd Metal Catalysts for Cross-Couplings and Related Reactions in the 21st Century: A Critical Review
- 1,347citations
- Q1SCImago
- 2018year
Short summary
Pd metal catalysts, previously limited to the Heck reaction, are now effectively used for most cross-coupling reactions, with recent advances focusing on mechanistic understanding and novel reactivity approaches.
AI-generated from the title and abstract; the full text is not read.
Key points
- Pd metal catalysts, once confined to the Heck reaction, now facilitate a broader range of cross-coupling reactions.
- Recent research focuses on understanding the mechanistic pathways of Pd metal catalysis.
- Novel approaches are being developed to improve the reactivity of Pd metal catalysts.
- The review covers both academic advancements and current industrial applications.
AI-generated from the title and abstract; the full text is not read.
Abstract
Cross-couplings and related reactions are a class of highly efficient synthetic protocols that are generally promoted by molecular Pd species as catalysts. However, catalysts based on more or less highly dispersed Pd metal have been also employed for this purpose, and their use, which was largely limited to the Heck reaction until the turn of the century, has been extended in recent years to most reactions of this class. This review provides a critical overview on these recent applications of Pd metal catalysts. Particular attention is devoted to the discussion of the mechanistic pathways that have been proposed to explain the catalytic role of Pd metal. Furthermore, the most outstanding Pd metal based catalytic systems that have emerged are illustrated, together with the development of novel approaches to boost the reactivity of Pd metal. A section summarizing the current industrial applications of Pd metal catalyzed reactions of this kind concludes the review.
The authors' abstract, as published at the source. Chemical Reviews, 2018 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry