Biochemical and Biophysical Research Communications· 2017Q2· Review
Lipid peroxidation in cell death
- 1,820citations
- Q2SCImago
- 2017year
Short summary
Lipid hydroperoxides, arising from excessive oxidation of cell membrane lipids, are increasingly recognized as critical mediators of cell death and disease, altering membrane integrity and modifying cellular components.
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Key points
- Lipid hydroperoxides are critical mediators of cell death and disease.
- Oxidation of lipids alters cell membrane physical properties.
- Lipid peroxidation can covalently modify proteins and nucleic acids.
- The review covers synthesis, toxicity, degradation, detection, and control of lipid peroxides.
AI-generated from the title and abstract; the full text is not read.
Abstract
Disruption of redox homeostasis is a key phenotype of many pathological conditions. Though multiple oxidizing compounds such as hydrogen peroxide are widely recognized as mediators and inducers of oxidative stress, increasingly, attention is focused on the role of lipid hydroperoxides as critical mediators of death and disease. As the main component of cellular membranes, lipids have an indispensible role in maintaining the structural integrity of cells. Excessive oxidation of lipids alters the physical properties of cellular membranes and can cause covalent modification of proteins and nucleic acids. This review discusses the synthesis, toxicity, degradation, and detection of lipid peroxides in biological systems. Additionally, the role of lipid peroxidation is highlighted in cell death and disease, and strategies to control the accumulation of lipid peroxides are discussed.
The authors' abstract, as published at the source. Biochemical and Biophysical Research Communications, 2017 · DOI ↗
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Field: Biochemistry (Medicine)
BiochemistryMedicine