Nutrients· 2020Q1· Review
Flavonoids as Anticancer Agents
- 1,274citations
- Q1SCImago
- 2020year
Short summary
Flavonoids, found in fruits, vegetables, and beverages like green tea, exhibit anticancer properties by modulating ROS, arresting cell cycles, inducing apoptosis, and suppressing cancer cell proliferation and invasiveness.
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Key points
- Flavonoids are polyphenolic compounds found in fruits, vegetables, and beverages.
- They possess anticancer effects by modulating reactive oxygen species (ROS) and related enzymes.
- Flavonoids can arrest the cell cycle and induce apoptosis and autophagy in cancer cells.
- They suppress cancer cell proliferation and invasiveness, acting as pro-oxidants in cancer cells.
AI-generated from the title and abstract; the full text is not read.
Abstract
Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids, flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants. Fruits, vegetables, plant-derived beverages such as green tea, wine and cocoa-based products are the main dietary sources of flavonoids. Flavonoids have been shown to possess a wide variety of anticancer effects: they modulate reactive oxygen species (ROS)-scavenging enzyme activities, participate in arresting the cell cycle, induce apoptosis, autophagy, and suppress cancer cell proliferation and invasiveness. Flavonoids have dual action regarding ROS homeostasis-they act as antioxidants under normal conditions and are potent pro-oxidants in cancer cells triggering the apoptotic pathways and downregulating pro-inflammatory signaling pathways. This article reviews the biochemical properties and bioavailability of flavonoids, their anticancer activity and its mechanisms of action.
The authors' abstract, as published at the source. Nutrients, 2020 · DOI ↗
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Field: Biochemistry (Medicine)
BiochemistryMedicine