Oxidative Medicine and Cellular Longevity· 2016Q1· Review
Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?
- 1,155citations
- Q1SCImago
- 2016year
Short summary
The failure of antioxidant trials to prevent or cure chronic diseases may stem from their inability to target both oxidative stress and inflammation simultaneously, suggesting a need for agents that address this interdependence.
AI-generated from the title and abstract; the full text is not read.
Key points
- Antioxidant trials have largely failed to prevent or cure chronic diseases.
- Oxidative stress and inflammation are closely related and can induce each other.
- The failure of antioxidant trials may be due to a lack of agents targeting both processes simultaneously.
- Nonselective agents may block beneficial pathways while exaggerating others.
AI-generated from the title and abstract; the full text is not read.
Abstract
Oxidative stress has been implicated in many chronic diseases. However, antioxidant trials are so far largely unsuccessful as a preventive or curative measure. Chronic low-grade inflammatory process, on the other hand, plays a central role in the pathogenesis of a number of chronic diseases. Oxidative stress and inflammation are closely related pathophysiological processes, one of which can be easily induced by another. Thus, both processes are simultaneously found in many pathological conditions. Therefore, the failure of antioxidant trials might result from failure to select appropriate agents that specifically target both inflammation and oxidative stress or failure to use both antioxidants and anti-inflammatory agents simultaneously or use of nonselective agents that block some of the oxidative and/or inflammatory pathways but exaggerate the others. To examine whether the interdependence between oxidative stress and inflammation can explain the antioxidant paradox we discussed in the present review the basic aspects of oxidative stress and inflammation and their relationship and dependence.
The authors' abstract, as published at the source. Oxidative Medicine and Cellular Longevity, 2016 · DOI ↗
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Field: Biochemistry (Medicine)
BiochemistryMedicine