Translational Psychiatry· 2026Q1
A framework and practical guide for conducting double-blind randomized clinical trials combining transcranial electrical stimulation and psychotherapy
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- Q1SCImago
- 2026year
Short summary
A new framework and practical guide addresses methodological challenges for designing double-blind randomized clinical trials that combine transcranial electrical stimulation (tES) with psychotherapy.
AI-generated from the title and abstract; the full text is not read.
Key points
- Presents a conceptual guide and framework for designing double-blind randomized trials combining tES and psychotherapy.
- Addresses unique methodological challenges inherent in combining these two treatment modalities.
- Provides practical guidelines covering target identification, blinding, regulatory issues, personnel, and equipment.
- Aims to improve the quality and interpretability of research in the tES-psychotherapy field.
AI-generated from the title and abstract; the full text is not read.
Abstract
Transcranial electrical stimulation (tES) is a non-invasive technique for modulating neural activity with minimal side effects, making it ideal for delivery concurrent with evidence-based psychotherapy. However, combining these modalities introduces unique methodological challenges that should be carefully addressed to ensure rigorous clinical trials with interpretable results. This article provides a conceptual guide and initial framework for designing and conducting double-blind randomized controlled trials that combine tES with evidence-based psychotherapy. We present a conceptual model for understanding the bidirectional influences between tES and evidence-based psychotherapy, outline critical considerations for study design, and provide practical guidelines for trial implementation. Drawing from recent clinical trials and established best practices, we also address key issues including target identification, blinding procedures, regulatory considerations, personnel requirements, and equipment needs. This guide is intended for investigators planning to conduct tES-psychotherapy studies and aims to enhance the quality and interpretability of research in this emerging field.
The authors' abstract, as published at the source. Translational Psychiatry, 2026 · DOI ↗
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Field: Neurology (Neuroscience)
NeurologyNeuroscience