Nature Communications· 2018Q1
Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing
- 1,157citations
- Q1SCImago
- 2018year
Short summary
Injectable antibacterial conductive cryogels, made from carbon nanotube (CNT) and functionalized chitosan, rapidly recover shape and absorb blood, proving superior to gauze and gelatin sponge in animal models for severe bleeding and wound healing.
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Key points
- Injectable cryogels combine antibacterial and conductive properties with shape memory for hemorrhage control.
- Cryogels show rapid blood absorption and shape recovery, outperforming gauze and gelatin sponge in blood clotting and cell adhesion.
- QCSG/CNT4 formulation demonstrated superior hemostatic efficacy in mouse liver/tail injury and rabbit liver defect models.
- Cryogels also showed improved wound healing performance compared to Tegaderm™ film.
AI-generated from the title and abstract; the full text is not read.
Abstract
Developing injectable antibacterial and conductive shape memory hemostatic with high blood absorption and fast recovery for irregularly shaped and noncompressible hemorrhage remains a challenge. Here we report injectable antibacterial conductive cryogels based on carbon nanotube (CNT) and glycidyl methacrylate functionalized quaternized chitosan for lethal noncompressible hemorrhage hemostasis and wound healing. These cryogels present robust mechanical strength, rapid blood-triggered shape recovery and absorption speed, and high blood uptake capacity. Moreover, cryogels show better blood-clotting ability, higher blood cell and platelet adhesion and activation than gelatin sponge and gauze. Cryogel with 4 mg/mL CNT (QCSG/CNT4) shows better hemostatic capability than gauze and gelatin hemostatic sponge in mouse-liver injury model and mouse-tail amputation model, and better wound healing performance than Tegaderm™ film. Importantly, QCSG/CNT4 presents excellent hemostatic performance in rabbit liver defect lethal noncompressible hemorrhage model and even better hemostatic ability than Combat Gauze in standardized circular liver bleeding model.
The authors' abstract, as published at the source. Nature Communications, 2018 · DOI ↗
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Field: Hematology
HematologyMedicine