Physiological Reviews· 2018Q1· Review
Wound Healing: A Cellular Perspective
- 2,924citations
- Q1SCImago
- 2018year
Short summary
Recent advances in single-cell technologies are revealing unprecedented detail about the diverse cell types and their dynamic interactions crucial for wound healing.
AI-generated from the title and abstract; the full text is not read.
Key points
- Wound healing involves distinct phases coordinated by various cell types.
- Single-cell technologies reveal heterogeneity and stem cell plasticity during injury.
- Microenvironmental factors like mechanical forces and oxygen levels significantly impact cellular function.
- Deciphering cellular alterations in diseased states can lead to therapeutic solutions.
AI-generated from the title and abstract; the full text is not read.
Abstract
Wound healing is one of the most complex processes in the human body. It involves the spatial and temporal synchronization of a variety of cell types with distinct roles in the phases of hemostasis, inflammation, growth, re-epithelialization, and remodeling. With the evolution of single cell technologies, it has been possible to uncover phenotypic and functional heterogeneity within several of these cell types. There have also been discoveries of rare, stem cell subsets within the skin, which are unipotent in the uninjured state, but become multipotent following skin injury. Unraveling the roles of each of these cell types and their interactions with each other is important in understanding the mechanisms of normal wound closure. Changes in the microenvironment including alterations in mechanical forces, oxygen levels, chemokines, extracellular matrix and growth factor synthesis directly impact cellular recruitment and activation, leading to impaired states of wound healing. Single cell technologies can be used to decipher these cellular alterations in diseased states such as in chronic wounds and hypertrophic scarring so that effective therapeutic solutions for healing wounds can be developed.
The authors' abstract, as published at the source. Physiological Reviews, 2018 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Rehabilitation
RehabilitationMedicine