Medicina· 2021Q2· Review
Diabetic Wound-Healing Science
- 852citations
- Q2SCImago
- 2021year
Short summary
Diabetic wounds, affecting 25% of diabetes patients, are hard to treat due to hyperglycemia-induced biofilms and impaired healing mechanisms like angiogenesis and inflammation.
AI-generated from the title and abstract; the full text is not read.
Key points
- Diabetic wounds affect an estimated 25% of patients with diabetes mellitus.
- Hyperglycemia in diabetes promotes biofilm formation and impairs wound healing.
- Key pathophysiological factors include impaired angiogenesis, neuropathy, chronic inflammation, and barrier disruption.
- Current and future treatments must target multiple causes of impaired healing.
AI-generated from the title and abstract; the full text is not read.
Abstract
Diabetes mellitus is an increasingly prevalent chronic metabolic disease characterized by prolonged hyperglycemia that leads to long-term health consequences. It is estimated that impaired healing of diabetic wounds affects approximately 25% of all patients with diabetes mellitus, often resulting in lower limb amputation, with subsequent high economic and psychosocial costs. The hyperglycemic environment promotes the formation of biofilms and makes diabetic wounds difficult to treat. In this review, we present updates regarding recent advances in our understanding of the pathophysiology of diabetic wounds focusing on impaired angiogenesis, neuropathy, sub-optimal chronic inflammatory response, barrier disruption, and subsequent polymicrobial infection, followed by current and future treatment strategies designed to tackle the various pathologies associated with diabetic wounds. Given the alarming increase in the prevalence of diabetes, and subsequently diabetic wounds, it is imperative that future treatment strategies target multiple causes of impaired healing in diabetic wounds.
The authors' abstract, as published at the source. Medicina, 2021 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine