ACS Nano· 2021Q1
Dual-Dynamic-Bond Cross-Linked Antibacterial Adhesive Hydrogel Sealants with On-Demand Removability for Post-Wound-Closure and Infected Wound Healing
- 1,060citations
- Q1SCImago
- 2021year
Short summary
A new hydrogel sealant, cross-linked by pH-sensitive coordinate bonds (catechol-Fe) and dynamic Schiff base bonds, demonstrates autonomous self-healing, on-demand removability, injectability, biocompatibility, antibacterial activity against MRSA, and hemostasis.
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Key points
- Hydrogel sealant created via dual-dynamic-bond cross-linking (Fe-catechol and Schiff base bonds).
- Achieves autonomous self-healing and on-demand removability.
- Demonstrates injectability, biocompatibility, hemostasis, and NIR responsiveness.
- Effective in closing skin incisions and promoting healing of MRSA-infected wounds in rat models.
AI-generated from the title and abstract; the full text is not read.
Abstract
The design and development of a smart bioadhesive hydrogel sealant with self-healing and excellent antibacterial activity to achieve high wound closure effectiveness and post-wound-closure care is highly desirable in clinical applications. In this work, a series of adhesive antioxidant antibacterial self-healing hydrogels with promising traits were designed through dual-dynamic-bond cross-linking among ferric iron (Fe), protocatechualdehyde (PA) containing catechol and aldehyde groups and quaternized chitosan (QCS) to enable the closure of skin incisions and promotion of methicillin-resistant Staphylococcus aureus (MRSA)-infected wound healing. The dual-dynamic-bond cross-linking of a pH-sensitive coordinate bond (catechol–Fe) and dynamic Schiff base bonds with reversible breakage and re-formation equips the hydrogel with excellent autonomous healing and on-demand dissolution or removal properties. Additionally, the hydrogel presents injectability, good biocompatibility and antibacterial activity, multifunctional adhesiveness, and hemostasis as well as NIR responsiveness. The in vivo evaluation in a rat skin incision model and infected full-thickness skin wound model revealed the high wound closure effectiveness and post-wound-closure care of the smart hydrogels, demonstrating its great potential in dealing with skin incisions and infected full-thickness skin wounds.
The authors' abstract, as published at the source. ACS Nano, 2021 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine