International Journal of Molecular Sciences· 2017Q1· Review
Diabetes and Wound Angiogenesis
- 995citations
- Q1SCImago
- 2017year
Short summary
Diabetes mellitus type II impairs skin wound healing by disrupting angiogenesis across proliferative, remodeling, and maturation phases, leading to chronic non-healing wounds and limb amputation.
AI-generated from the title and abstract; the full text is not read.
Key points
- Diabetes mellitus type II negatively impacts all stages of skin wound healing.
- Impaired angiogenesis, characterized by poor vascular networks, is a key factor in non-healing diabetic wounds.
- Disruptions occur specifically in the proliferative, remodeling, and maturation phases of wound angiogenesis.
- The review examines therapeutic approaches aimed at improving diabetic wound healing.
AI-generated from the title and abstract; the full text is not read.
Abstract
Diabetes Mellitus Type II (DM2) is a growing international health concern with no end in sight. Complications of DM2 involve a myriad of comorbidities including the serious complications of poor wound healing, chronic ulceration, and resultant limb amputation. In skin wound healing, which has definite, orderly phases, diabetes leads to improper function at all stages. While the etiology of chronic, non-healing diabetic wounds is multi-faceted, the progression to a non-healing phenotype is closely linked to poor vascular networks. This review focuses on diabetic wound healing, paying special attention to the aberrations that have been described in the proliferative, remodeling, and maturation phases of wound angiogenesis. Additionally, this review considers therapeutics that may offer promise to better wound healing outcomes.
The authors' abstract, as published at the source. International Journal of Molecular Sciences, 2017 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine