Theranostics· 2018
Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration
- 909citations
- 2018year
Short summary
A novel injectable, self-healing, and antibacterial polypeptide-based hydrogel (FHE) was engineered to controllably release exosomes derived from adipose-derived mesenchymal stem cells (AMSCs-exo), significantly enhancing chronic diabetic wound healing and complete skin regeneration.
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Key points
- Developed an injectable, self-healing, and antibacterial polypeptide-based hydrogel (FHE).
- Engineered the hydrogel for stimuli-responsive release of adipose-derived mesenchymal stem cells exosomes (AMSCs-exo).
- Demonstrated synergistic enhancement of chronic diabetic wound healing and complete skin regeneration in vivo.
- Materials characterization, antibacterial activity, and cellular behavior were analyzed.
AI-generated from the title and abstract; the full text is not read.
Abstract
Rationale: Chronic nonhealing diabetic wound therapy and complete skin regeneration remains a critical clinical challenge. The controlled release of bioactive factors from a multifunctional hydrogel was a promising strategy to repair chronic wounds. Methods: Herein, for the first time, we developed an injectable, self-healing and antibacterial polypeptide-based FHE hydrogel (F127/OHA-EPL) with stimuli-responsive adipose-derived mesenchymal stem cells exosomes (AMSCs-exo) release for synergistically enhancing chronic wound healing and complete skin regeneration. The materials characterization, antibacterial activity, stimulated cellular behavior and in vivo full-thickness diabetic wound healing ability of the hydrogels were performed and analyzed.
The authors' abstract, as published at the source. Theranostics, 2018 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine