Biomacromolecules· 2026Q1
Bienzymatic Cascade Reaction-Mediated One-Pot Xyloglucan/Chitosan Hydrogel with Antimicrobial, Hemostatic, and Angiogenic Properties for Burn and Diabetic Wounds Repair
- 0citations
- Q1SCImago
- 2026year
Short summary
A one-pot, dual-crosslinked hydrogel made from modified chitosan and xyloglucan via a bienzymatic cascade reaction shows enhanced wound healing properties.
AI-generated from the title and abstract; the full text is not read.
Key points
- A one-pot hydrogel was fabricated using a bienzymatic cascade reaction of modified chitosan (CPA) and xyloglucan (XG).
- Dual crosslinking occurs through Schiff base formation and HRP-catalyzed phenol coupling.
- The hydrogel exhibits shear-thinning, self-healing, injectability, and superior mechanical properties.
- It possesses antimicrobial, hemostatic, and angiogenic properties, promoting rapid wound healing in animal models.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Chronic wounds present clinical challenges due to delayed healing, infection, and immune dysfunction. Most hydrogel dressings rely on crosslinking agents with potential adverse effects. This study introduces a one-pot, dual-crosslinked hydrogel fabricated via a bienzymatic cascade system using chitosan modified with phenol and arginine groups (CPA), xyloglucan (XG), horseradish peroxidase, and galactose oxidase (GalOx). The GalOx oxidizes XG to generate aldehydes, which form Schiff base bonds with the amino groups of CPA, creating the first gel network and releasing H2O2. The phenol groups in CPA are then catalyzed by H2O2 and HRP to form covalent bonds, establishing the second network. The hydrogel exhibits excellent mechanics, shear-thinning, self-healing, injectability, antimicrobial activity, angiogenesis promotion, and hemostatic properties. It shows superb biocompatibility and accelerates wound healing in burn and diabetic mouse models, outperforming commercial products. This hydrogel is a promising dressing for chronic wound therapy.
The authors' abstract, as published at the source. Biomacromolecules, 2026 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Rehabilitation
RehabilitationMedicine