Cell Metabolism· 2023Q1· Review
Tryptophan metabolism in health and disease
- 876citations
- Q1SCImago
- 2023year
Short summary
Tryptophan metabolism, via kynurenine, 5-hydroxytryptamine, and indole pathways, produces bioactive compounds that regulate inflammation, immunity, metabolism, and neurological function, with disorders linked to disease progression and clinical features.
AI-generated from the title and abstract; the full text is not read.
Key points
- Tryptophan metabolism involves kynurenine, 5-hydroxytryptamine, and indole pathways.
- Metabolites regulate inflammation, immunity, metabolism, and neurological function.
- Disordered tryptophan metabolism is associated with disease and clinical features.
- Key enzymes (IDO, TDO, KMO, TPH) are targets for disease treatment, including cancer.
AI-generated from the title and abstract; the full text is not read.
Abstract
Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, immune responses, and neurological function. Emerging evidence supports an intimate relationship between Trp metabolism disorder and diseases. The levels or ratios of Trp metabolites are significantly associated with many clinical features. Additionally, studies have shown that disease progression can be controlled by modulating Trp metabolism. Indoleamine-2,3-dioxygenase, Trp-2,3-dioxygenase, kynurenine-3-monooxygenase, and Trp hydroxylase are the rate-limiting enzymes that are critical for Trp metabolism. These key regulatory enzymes can be targeted for treating several diseases, including tumors. These findings provide novel insights into the treatment of diseases. In this review, we have summarized the recent research progress on the role of Trp metabolites in health and disease along with their clinical applications.
The authors' abstract, as published at the source. Cell Metabolism, 2023 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Biological Psychiatry
Biological PsychiatryNeuroscience