Nature Communications· 2018Q1· Review
Microbial tryptophan catabolites in health and disease
- 2,147citations
- Q1SCImago
- 2018year
Short summary
Gut microbes produce tryptophan catabolites that influence host health by interacting with the aryl hydrocarbon receptor (AHR), affecting the intestinal barrier, gut hormones, and systemic inflammation.
AI-generated from the title and abstract; the full text is not read.
Key points
- Microbial tryptophan catabolites are mediators of diet-induced host-microbial cross-talk.
- These metabolites can activate the aryl hydrocarbon receptor (AHR).
- They influence intestinal epithelial barrier function and gut hormone secretion.
- Effects can be anti-inflammatory, anti-oxidative, or toxic in systemic circulation.
AI-generated from the title and abstract; the full text is not read.
Abstract
Accumulating evidence implicates metabolites produced by gut microbes as crucial mediators of diet-induced host-microbial cross-talk. Here, we review emerging data suggesting that microbial tryptophan catabolites resulting from proteolysis are influencing host health. These metabolites are suggested to activate the immune system through binding to the aryl hydrocarbon receptor (AHR), enhance the intestinal epithelial barrier, stimulate gastrointestinal motility, as well as secretion of gut hormones, exert anti-inflammatory, anti-oxidative or toxic effects in systemic circulation, and putatively modulate gut microbial composition. Tryptophan catabolites thus affect various physiological processes and may contribute to intestinal and systemic homeostasis in health and disease.
The authors' abstract, as published at the source. Nature Communications, 2018 · DOI ↗
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Field: Biological Psychiatry
Biological PsychiatryNeuroscience