Science· 2018Q1
Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics
- 1,130citations
- Q1SCImago
- 2018year
Short summary
Upconversion nanoparticles (UCNPs) enable deep brain stimulation using near-infrared (NIR) light, overcoming visible light's penetration limits in brain tissue.
AI-generated from the title and abstract; the full text is not read.
Key points
- Upconversion nanoparticles (UCNPs) absorb near-infrared (NIR) light and emit visible light, enabling deep brain optogenetics.
- Transcranial NIR UCNP-mediated optogenetics successfully evoked dopamine release, induced brain oscillations, silenced seizures, and triggered memory recall.
- This technology allows for less-invasive optical neuronal activity manipulation compared to traditional methods.
- The potential for remote therapy is a key implication of this UCNP-based approach.
AI-generated from the title and abstract; the full text is not read.
Abstract
Optogenetics has revolutionized the experimental interrogation of neural circuits and holds promise for the treatment of neurological disorders. It is limited, however, because visible light cannot penetrate deep inside brain tissue. Upconversion nanoparticles (UCNPs) absorb tissue-penetrating near-infrared (NIR) light and emit wavelength-specific visible light. Here, we demonstrate that molecularly tailored UCNPs can serve as optogenetic actuators of transcranial NIR light to stimulate deep brain neurons. Transcranial NIR UCNP-mediated optogenetics evoked dopamine release from genetically tagged neurons in the ventral tegmental area, induced brain oscillations through activation of inhibitory neurons in the medial septum, silenced seizure by inhibition of hippocampal excitatory cells, and triggered memory recall. UCNP technology will enable less-invasive optical neuronal activity manipulation with the potential for remote therapy.
The authors' abstract, as published at the source. Science, 2018 · DOI ↗
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Field: Cellular and Molecular Neuroscience
Cellular and Molecular NeuroscienceNeuroscience