Diabetes· 2014Q1
Insulin Action in Brain Regulates Systemic Metabolism and Brain Function
- 662citations
- Q1SCImago
- 2014year
Short summary
Insulin receptors in the brain regulate peripheral metabolism (appetite, reproduction, body temperature, fat mass, glucose output, hypoglycemia response) and brain functions (neurotransmitter activity, cholesterol synthesis, mitochondrial function).
AI-generated from the title and abstract; the full text is not read.
Key points
- Insulin receptors are distributed throughout the brain.
- Brain insulin signaling regulates peripheral metabolism (appetite, reproduction, body temperature, fat mass, hepatic glucose output, hypoglycemia response).
- Insulin signaling in the brain also modulates neurotransmitter activity, cholesterol synthesis, and mitochondrial function.
- Disrupted brain insulin action impairs neuronal function, synaptogenesis, and tau phosphorylation, linking it to metabolic syndrome, mood disorders, and neurodegeneration.
AI-generated from the title and abstract; the full text is not read.
Abstract
Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are distributed throughout the brain. Insulin acts on these receptors to modulate peripheral metabolism, including regulation of appetite, reproductive function, body temperature, white fat mass, hepatic glucose output, and response to hypoglycemia. Insulin signaling also modulates neurotransmitter channel activity, brain cholesterol synthesis, and mitochondrial function. Disruption of insulin action in the brain leads to impairment of neuronal function and synaptogenesis. In addition, insulin signaling modulates phosphorylation of tau protein, an early component in the development of Alzheimer disease. Thus, alterations in insulin action in the brain can contribute to metabolic syndrome, and the development of mood disorders and neurodegenerative diseases.
The authors' abstract, as published at the source. Diabetes, 2014 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Endocrine and Autonomic Systems
Endocrine and Autonomic SystemsNeuroscience