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Science· 2012Q1

Crystal Structure of the Calcium Release–Activated Calcium Channel Orai

Xiaowei Hou, Leanne Pedi, Melinda M. Diver, Stephen B. Long

Short summary

The crystal structure of the Drosophila melanogaster Orai protein reveals a hexameric assembly forming a central ion pore, with a glutamate ring acting as the selectivity filter and a basic region potentially stabilizing the closed state.

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Field: Sensory Systems

Sensory SystemsNeuroscience