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The Journal of Organic Chemistry· 2026Q2

TsCl-Mediated, Copper-Catalyzed Deoxygenative Difluoromethoxylation Reaction of Quinoline- N -Oxides

Linda Wang, Xi Zhang, Wenhui Wang, Jingxuan Lin et al.

Short summary

A new copper-catalyzed reaction uses TsCl and ethyl bromodifluoroacetate to synthesize 2-difluoromethoxy quinoline derivatives from quinoline-N-oxides in good to excellent yields.

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