Organic Letters· 2026Q1

Polarity-Matched Formal [1 + 4] Annulation of Fluoroalkyl Hydrazonoyl Halides with α-Halo Hydrazone-Derived Azoalkenes

Junjiao Wang, Yang Li, Na Li, Kaijian Zhu et al.

0citations
Q1SCImago
2026year

Short summary

A new base-promoted reaction enables the formal [1 + 4] annulation of fluoroalkyl hydrazonoyl halides with α-halo acylhydrazone-derived azoalkenes, yielding CF2H- and CF3-substituted pyrazolines.

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Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics