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ACS Applied Materials & Interfaces· 2026Q1

Dissolving Microneedles Loaded with Lipid Nanoparticles for Co-Delivery of siTNF-α and Dexamethasone as a Dual-Action Therapy for Psoriasis

Yaxin Cheng, Yunfeng Han, Xueying Gu, Yulu Liu et al.

Short summary

A hyaluronic acid dissolving microneedle platform co-delivers siTNF-α and dexamethasone encapsulated within novel lipid nanoparticles (LNPs) for enhanced psoriasis treatment, significantly reducing disease severity in a mouse model.

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Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics