Viruses· 2026Q1· Review
Role of Ion Channels in the Pathophysiology of SARS-CoV-2
- 0citations
- Q1SCImago
- 2026year
Short summary
SARS-CoV-2 utilizes ion channels, including viroporins, to facilitate viral replication, assembly, and immune evasion, making them potential therapeutic targets.
AI-generated from the title and abstract; the full text is not read.
Key points
- Ion channels, especially viroporins, play a critical role in SARS-CoV-2 pathophysiology.
- These channels are involved in viral replication, assembly, and immune evasion.
- Viral proteins with membrane-interacting properties (viroporins) promote viral survival and trigger host defense.
- Ion channels represent potential therapeutic targets for COVID-19.
AI-generated from the title and abstract; the full text is not read.
Abstract
In the pathophysiology of SARS-CoV-2, the critical role of ion channels has become increasingly evident during the COVID-19 crisis. This review offers a comprehensive analysis of the functions of ion channels, including viroporins, in both the viral life cycle and the host immune response. It explores how ion channels facilitate viral replication, assembly, and immune evasion. Moreover, this review critically examines the molecular mechanisms underpinning SARS-CoV-2 infection, with a particular emphasis on the integral role of viral proteins exhibiting membrane-interacting properties, collectively named viroporins, in promoting viral survival and triggering host defense mechanisms, highlighting their potential as therapeutic targets. By unraveling these complex interactions, this review aims to increase our understanding of COVID-19 pathophysiology.
The authors' abstract, as published at the source. Viruses, 2026 · DOI ↗
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Field: Sensory Systems
Sensory SystemsNeuroscience