Science· 2012Q1

Elementary Ca <sup>2+</sup> Signals Through Endothelial TRPV4 Channels Regulate Vascular Function

Swapnil K. Sonkusare, Adrian D. Bonev, Jonathan Ledoux, Wolfgang Liedtke et al.

548citations
Q1SCImago
2012year

Short summary

Local Ca2+ signals ('sparklets') through single TRPV4 channels in endothelial cells cause maximal vasodilation by activating IK and SK potassium channels.

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Field: Sensory Systems

Sensory SystemsNeuroscience