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International Journal of Molecular Sciences· 2026Q1

S-Ketamine Preserves Oxidative Metabolism and Reduces Metabolic Stress During Neuronal Hyperexcitability

Georg Riepe, Jonas Schunack, Jörg Rösner, Iwona Wallach et al.

Short summary

S-ketamine at 100 µM preserves neuronal oxidative metabolism under physiological conditions and reduces metabolic stress during pathological hyperexcitability, abolishing seizure-like events and normalizing oxygen consumption during Mg2+-free conditions.

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Field: Developmental Neuroscience

Developmental NeuroscienceNeuroscience