Organic Letters· 2026Q1
Trifluoroallyl Sulfonium Salts: Reagents for Highly Regioselective Trifluoroallylation
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- Q1SCImago
- 2026year
Short summary
Novel trifluoroallyl sulfonium salts (TFASs) enable efficient and regioselective synthesis of allylic trifluoromethyl-terminal alkenes via reaction with organozinc reagents under copper catalysis.
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Key points
- Developed novel trifluoroallyl sulfonium salts (TFASs).
- TFASs are bench-stable and scalable reagents.
- TFASs react with organozinc reagents under copper catalysis.
- Reaction yields allylic trifluoromethyl-terminal alkenes with high regioselectivity.
- Subsequent transformations demonstrate synthetic utility.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract We report the design, synthesis, and application of novel bench-stable and scalable trifluoroallylating reagents, trifluoroallyl sulfonium salts (TFASs), which readily react with a series of organozinc reagents under copper catalysis to afford allylic trifluoromethyl-terminal alkenes with high efficiency and regioselectivity. Subsequent transformations of the resulting products further demonstrate the synthetic utility of these reagents.
The authors' abstract, as published at the source. Organic Letters, 2026 · DOI ↗
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