Organic Letters· 2026Q1
Iron-Catalyzed Defluorinative Alkylation for Accessing Cyclic Acetal– gem -Difluoroalkenes
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- Q1SCImago
- 2026year
Short summary
An Fe-catalyzed reaction couples trifluoromethyl alkenes with alkyl iodides to form cyclic acetal-gem-difluoroalkenes, useful in medicinal chemistry.
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Key points
- Developed an Fe-catalyzed reductive defluorinative cross-coupling reaction.
- Successfully synthesized cyclic acetal-gem-difluoroalkenes from trifluoromethyl alkenes and alkyl iodides.
- The protocol yields five- or seven-membered cyclic acetal-embodied fluorinated scaffolds.
- Enables rapid assembly of structurally diverse, pharmaceutically relevant scaffolds.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Cyclic acetals and gem-difluoroalkenes are proven structural motifs in medicinal chemistry, yet their modular incorporation into a densely functionalized hybrid architecture remains an uncharted frontier. Herein, we disclose an Fe-catalyzed reductive defluorinative cross-coupling between trifluoromethyl alkenes and 1,3-dioxolanyl- or 1,3-dioxepanyl-substituted alkyl iodides, enabling the rapid assembly of five- or seven-membered cyclic acetal-embodied fluorinated scaffolds, respectively. This protocol enriches defluorinative coupling versatility and offers streamlined access to structurally diverse pharmaceutically relevant scaffolds.
The authors' abstract, as published at the source. Organic Letters, 2026 · DOI ↗
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Field: Pharmaceutical Science
Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics