Proceedings of the National Academy of Sciences· 2012Q1

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

Luc Pilotte, Pierre Larrieu, Vincent Stroobant, Didier Colau et al.

570citations
Q1SCImago
2012year

Short summary

Inhibition of the hepatic enzyme tryptophan 2,3-dioxygenase (TDO) restores the ability of mice to reject TDO-expressing tumors, establishing a new mechanism of tumoral immune resistance and a potential therapeutic target.

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Field: Biological Psychiatry

Biological PsychiatryNeuroscience