eLife· 2020Q1
A connectome and analysis of the adult Drosophila central brain
- 1,231citations
- Q1SCImago
- 2020year
Short summary
Researchers mapped the neural circuitry of most of the adult fruit fly central brain, defining novel cell types and providing an exhaustive atlas of neurons and their chemical synapses.
AI-generated from the title and abstract; the full text is not read.
Key points
- Developed new methods for preparing, imaging, aligning, segmenting, and proofreading large neural circuit datasets.
- Defined novel cell types and created an exhaustive atlas of cell examples and types for the Drosophila central brain.
- Provided detailed circuits of neurons and their chemical synapses for most of the central brain.
- Released data publicly with simplified access and procedures linking neurons to genetic reagents.
AI-generated from the title and abstract; the full text is not read.
Abstract
The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster . Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed to answer circuit questions, and provide procedures linking the neurons defined by our analysis with genetic reagents. Biologically, we examine distributions of connection strengths, neural motifs on different scales, electrical consequences of compartmentalization, and evidence that maximizing packing density is an important criterion in the evolution of the fly’s brain.
The authors' abstract, as published at the source. eLife, 2020 · DOI ↗
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Field: Cellular and Molecular Neuroscience
Cellular and Molecular NeuroscienceNeuroscience