Key papers in Family Practice
Pofolia’s corpus holds 86 papers from the Family Practice subfield (2012–2024). The list below starts with the most cited.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”.
Information bias in health research: definition, pitfalls, and adjustment methods
Journal of Multidisciplinary Healthcare · 2016 · Q1 · FWCI 62.60 · 3,016 citations · Open access
This paper defines information bias (misclassification) as a common source of error in health research stemming from how study measurements are obtained, and highlights its impact on research validity.
Interventions for enhancing medication adherence
Cochrane Database of Systematic Reviews · 2014 · FWCI 194.55 · 2,977 citations
A comprehensive review of 182 randomized controlled trials (RCTs) found that current interventions to improve medication adherence are complex, heterogeneous, and largely ineffective, with only a minority of high-quality studies demonstrating improvements in both adherence and clinical outcomes.
A new taxonomy for describing and defining adherence to medications
British Journal of Clinical Pharmacology · 2012 · Q1 · SJR 1.00 · FWCI 28.77 · 2,003 citations · Open access
This review proposes a new, transparent taxonomy for medication adherence, distinguishing between the process of taking medication and the science studying it, and dividing the former into quantifiable phases: Initiation, Implementation, and Discontinuation.
Improving Diagnosis in Health Care
National Academies Press eBooks · 2015 · FWCI 21.96 · 1,368 citations
Diagnostic errors, including inaccurate or delayed diagnoses, are prevalent across all healthcare settings and cause significant harm to patients, often with devastating consequences.
Medication Adherence Measures: An Overview
BioMed Research International · 2015 · Q2 · FWCI 47.74 · 1,285 citations · Open access
This paper reviews subjective and objective tools for measuring medication adherence, highlighting that no single perfect measure exists.
Understanding Patients’ Adherence-Related Beliefs about Medicines Prescribed for Long-Term Conditions: A Meta-Analytic Review of the Necessity-Concerns Framework
PLoS ONE · 2013 · Q1 · FWCI 34.08 · 1,156 citations · Open access
A meta-analysis of 94 studies (N=25,072) confirms that patients' beliefs significantly predict adherence to long-term medications. Higher perceived necessity for treatment (OR=1.74) and lower concerns about side effects (OR=0.50) are strongly linked to better adherence.
Cognitive biases associated with medical decisions: a systematic review
BMC Medical Informatics and Decision Making · 2016 · Q1 · SJR 1.00 · FWCI 8.40 · 971 citations · Open access
A systematic review of 20 studies found that common cognitive biases like overconfidence and anchoring affect physicians, leading to diagnostic inaccuracies in 36.5-77% of scenarios and management errors in 71.4% of studies.
Adherence to cardiovascular therapy: a meta-analysis of prevalence and clinical consequences
European Heart Journal · 2013 · Q1 · SJR 5.00 · FWCI 6.16 · 947 citations
Poor adherence to cardiovascular medications is common, with roughly 40% of patients not meeting the 80% adherence threshold, and this suboptimal adherence significantly increases the risk of cardiovascular disease (CVD) and all-cause mortality.
Economic impact of medication non-adherence by disease groups: a systematic review
BMJ Open · 2018 · Q1 · FWCI 14.28 · 912 citations · Open access
Medication non-adherence imposes a significant economic burden on healthcare systems, with annual costs per person ranging from $949 to $44,190 across various diseases.
Cognitive Load Theory: Implications for medical education: AMEE Guide No. 86
Medical Teacher · 2014 · Q1 · SJR 1.00 · FWCI 28.40 · 902 citations
Cognitive Load Theory (CLT) offers a framework for understanding learning limitations in medical education by identifying three types of cognitive load (intrinsic, extraneous, germane) that impact limited working memory. Instructional techniques can be designed to reduce extraneous load and manage intrinsic load, optimizing learning.
Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD): the TRIPOD Statement
British journal of surgery · 2015 · Q1 · SJR 1.00 · FWCI 17.09 · 883 citations · Open access
The TRIPOD Statement provides a 22-item checklist to ensure transparent and complete reporting of studies that develop, validate, or update prediction models for diagnosis or prognosis.
Self-report measures of medication adherence behavior: recommendations on optimal use
Translational Behavioral Medicine · 2015 · Q1 · SJR 1.00 · FWCI 38.79 · 826 citations · Open access
Self-report is the most common method for assessing medication adherence, but it tends to overestimate adherence and has low sensitivity, though it can predict clinical outcomes.
Adherence in Hypertension
Circulation Research · 2019 · Q1 · SJR 5.00 · FWCI 60.70 · 809 citations
Suboptimal adherence to hypertension medication, including failure to initiate, take as prescribed, or persist long-term, is a major contributor to uncontrolled blood pressure and related deaths.
Determinants of patient adherence: a review of systematic reviews
Frontiers in Pharmacology · 2013 · Q1 · SJR 1.00 · FWCI 3.40 · 798 citations · Open access
A review of 51 systematic reviews found 771 individual factors influencing medication non-adherence, primarily related to implementation rather than persistence, highlighting the complexity of predicting patient adherence.
Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD)
Circulation · 2015 · Q1 · SJR 8.00 · FWCI 9.49 · 786 citations · Open access
The TRIPOD Initiative has developed a 22-item checklist to standardize and improve the transparent reporting of studies that develop, validate, or update prediction models for healthcare.
Exercise is the Real Polypill
Physiology · 2013 · Q1 · SJR 2.00 · FWCI 26.01 · 784 citations
Regular exercise offers comparable or superior cardiovascular disease prevention and treatment benefits to the proposed "polypill" drug strategy, acting as a drug-free, evolutionarily shaped intervention.
Poor medication adherence in type 2 diabetes: recognizing the scope of the problem and its key contributors
Patient Preference and Adherence · 2016 · Q1 · FWCI 32.71 · 774 citations · Open access
At least 45% of type 2 diabetes patients fail to achieve adequate glycemic control, with poor medication adherence being a major factor. This issue leads to worse health outcomes and increased healthcare costs.
Interventions to Improve Adherence to Self-administered Medications for Chronic Diseases in the United States
Annals of Internal Medicine · 2012 · Q1 · SJR 2.00 · FWCI 26.46 · 768 citations
Policy interventions reducing out-of-pocket medication costs, systems-level case management, and patient education with behavioral support effectively improve adherence to self-administered medications for chronic diseases.
Adherence to Therapies in Patients with Type 2 Diabetes
Diabetes Therapy · 2013 · Q1 · SJR 1.00 · FWCI 19.85 · 738 citations · Open access
Less than 50% of type 2 diabetes patients achieve recommended glycemic goals, often due to poor adherence to complex medication, diet, and lifestyle recommendations.
Adherence and health care costs
Risk Management and Healthcare Policy · 2014 · Q2 · FWCI 27.19 · 721 citations · Open access
Medication nonadherence significantly impacts health outcomes and drives up US healthcare costs, with specific chronic diseases like diabetes and asthma showing substantial cost increases.
Recently added
Large Language Model Influence on Diagnostic Reasoning
JAMA Network Open · 2024 · Q1 · SJR 3.00 · FWCI 214.87 · 570 citations
An LLM did not significantly improve physician diagnostic reasoning scores (76% vs 74%) or reduce time spent per case compared to conventional resources in a randomized trial of 50 physicians.
Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems
Nature Reviews Drug Discovery · 2023 · Q1 · SJR 32.00 · FWCI 95.79 · 454 citations · Open access
Next-generation drug delivery systems (DDSs) offer a promising solution to poor medication adherence by directly addressing common impediments like frequent dosing, adverse effects, and delayed action.
Using cognitive psychology to understand GPT-3
Proceedings of the National Academy of Sciences · 2023 · Q1 · SJR 3.00 · FWCI 97.67 · 465 citations
GPT-3 exhibits impressive decision-making and learning abilities, outperforming humans in a multi-armed bandit task, but fails in causal reasoning and is easily misled by minor task changes.
Polypill Strategy in Secondary Cardiovascular Prevention
New England Journal of Medicine · 2022 · Q1 · SJR 18.00 · FWCI 57.37 · 319 citations · Open access
A polypill containing aspirin, ramipril, and atorvastatin significantly reduced major adverse cardiovascular events by 24% (HR 0.76) compared to usual care in patients within 6 months of myocardial infarction.
Medication Adherence and Blood Pressure Control: A Scientific Statement From the American Heart Association
Hypertension · 2021 · Q1 · SJR 3.00 · FWCI 34.69 · 301 citations
A scientific statement from the American Heart Association highlights that medication nonadherence is a key factor contributing to the persistent gap in hypertension control, despite widespread treatment and progress in reducing heart disease and stroke.
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